søndag den 12. september 2021

 THE 
KILLER VACCINE WORLDWIDE
7.9 BILLION PEOPLE
By
Søren Nielsen
2021




The Covid-19 Vaccine should be Halted and Discontinued Immediately Worldwide.

Let us be under no illusions, it’s not only "experimental", it’s a Big Pharma "killer vaccine" which modifies the human genome. 

The evidence of mortality and morbidity resulting from vaccine inoculation both present (official data) and future (e.g. undetected microscopic blood clots) is overwhelming.


Numerous scientific studies published independently confirm the nature of the Covid-19 mRNA vaccine which is being imposed on all humanity.
 
The stated objective is to enforce the Worldwide vaccination of 7.9 billion people in more than 190 countries, to be followed by the imposition of a digitized "vaccine passport". 

Needless to say this is a multi-billion dollar operation for Big Pharma.

Bill Gates and WHO’s Director General Dr. Tedros
The global vaccine project entitled COVAX is coordinated Worldwide by the WHO, GAVI, CEPI, the Bill and Melinda Gates Foundation in liaison with the World Economic Forum (WEF),  the Wellcome Trust, DARPA and Big Pharma which is increasingly dominated by the Pfizer-GSK partnership established barely four months before the onset of the Covid-19 crisis in early January 2020.

The Covid-19 Timeline.
Fake figures of covid-19 positive cases and covid-19 related deaths

Lies upon lies.

There is a complex timeline. 

The covid crisis is marked by several stages leading up to the implementation of mass vaccination Worldwide in December 2020.

A fake Worldwide Public Health Emergency (PHEIC) was announced by the WHO on January 30, 2020 (based on 83 positive cases Worldwide outside China), followed by the onset of the crisis in air travel and international commodity trade (Trump on January 31, 2020), the February 20, 2020 financial crash, the March 11, 2020 lockdown, followed by the second, third waves and fourth waves. 

When will it end?

The March 11, 2020 Lockdown and Its Devastating Social and Economic Consequences.

Starting on March 11, 2020, 44,279 so-called confirmed RT-PCR "positive cases" (Worldwide out of China) and 1440 Covid deaths were used to justify:
  • social confinement,
  • the lockdown and closure of 190 national economies, crisis of the global economy,
  • extensive corporate bankruptcies in key sectors of economic activity,
  • the outright elimination of small and medium sized enterprises,
  • the triggering of poverty and mass unemployment,
  • social distancing, the face mask, no social and family gatherings,
  • Devastating impacts of mental health,
  • an engineered crisis of the national health system,
  • the closure of schools, colleges and universities,
  • the closure of museums, concert halls, culture and sport events,
  • institutional collapse and the disruption of civil society.
The stated objective has always been to save lives. 

The outcome of these policies have literally destroyed people’s lives. 

Millions of people Worldwide have been driven into extreme poverty.

And then ten months later the Covid-19 vaccine has come to our rescue.

It was announced in early November 2020 and launched Worldwide in late December.

The fear campaign has spearheaded compliance and acceptance to higher authority.

The mRNA vaccine was presented as an everlasting solution, as a means to curbing the epidemic, saving lives, reopening our shattered national economies and restoring a sense of normality in our daily lives.

A massive propaganda campaign was initiated in support of the vaccine.

A fake promise of a new life. 

A return to reason and normalcy.

All of this turned out to be an illusion, spearheaded by lies and fabrications.

The ideology of the financial elites and the billionaire foundations was imposed: The vaccine was upheld as a means to carrying out the World Economic Forum’s "Great Reset":
"You’ll Own Nothing and Be Happy": a  stylized future predicated on debt and extreme poverty coupled with a "killer vaccine".


What is envisaged under "The Great Reset" (Klaus Schwab) is a scenario whereby the global creditors will have appropriated by 2030 the World’s wealth, while impoverishing large sectors of the World Population.

The billionaire elites do not hide their intent. 

In 2030 "You’ll own nothing, And you’ll be happy."

Lies through omission: the dramatic trend in mortality and morbidity related to the vaccine (confirmed by official sources) since early January 2021 had been carefully obfuscated.

"Killer Virus" or "Killer Vaccine"?
The first question which stands out is: Do We Need a Vaccine?

The answer is NO

There is no scientific basis whatsoever which justifies the gene-edited vaccine as a means to saving lives and protecting people’s health Worldwide.

The alleged "scientific justification" for the vaccination program relies on the three simple and misleading "phrases" or "labels" which are totally invalid:

SARS-COV-2 is a "killer virus".

There is a rising Worldwide trend of covid-19 infection.

People are dying as a result of the covid-19 infection.

1. SARS-CoV-2 is "a killer virus".
That’s the cornerstone of the 24/7 fear and media disinformation campaign upheld by persistent statements by politicians and national health authorities.

Both the peer-reviewed as well the WHO, CDC "official" definitions of SARS-CoV-2 say exactly the opposite. 

Their definitions of SARS-2 repeal their own lies.

2. There is a Rising Worldwide Trend of Covid-19 infection.
This alleged trend is said to be corroborated by a rapidly increasing number of covid positive cases.

The methodology used to generate these figures is dependent upon the WHO sponsored Real Time Reverse Transcription Polymerase Chain Reaction (rRT-PCR) test, the estimates of which are tabulated Worldwide by the national health authorities.

While the estimates of the rRT-PCR have been questioned from the very outset, it is now confirmed by the WHO in a January 20, 2021 advisory that the rRT-PCR test adopted as a means to detecting the SARS-COV-2 virus cases is TOTALLY invalid

(This pertains to Covid positive data tabulated since late January 2020).

3. People are Dying as a Result of the Covid-19 Infection.
We are told that there is a rising trend of Covid-19 mortality.

Namely deaths which are allegedly the result of  the SARS-2 viral infection.

There is ample evidence that these Covid-19 related probable causes of death and the underlying data on Covid-19 mortality are manipulated by the national health authorities. 

Tests, autopsies and postmortems are not conducted. 

The mortality statistics pertaining to Covid-19 are TOTALLY invalid.

In summary.
1. There is no killer virus.

2. The measurement of covid positive cases is invalid.

3. The Covid-19 mortality data are manipulated.

All of these statements are amply documented.

I should mention that the so-called "emergency use" clause to justify an experimental and unapproved vaccine is also invalid.

Why? Because the emergency use criterion relies on erroneous estimates of the rRT-PCR covid positive cases (fake) and Covid-19 related mortality data, both of which are invalid.

The Vaccine. Hidden Agenda?
The vaccine does not save lives nor does it contain the pandemic, because there is no pandemic. 

It’s a money-making operation for Big Pharma in the hundreds of billions of dollars.

Moreover, it’s not a one time vaccine jab. 

Several doses are contemplated. It is slated to extend over a period of at least two years.

It is applied Worldwide without exceptions. 

Not a single country with the exception of Burundi, Tanzania and Haiti had the courage to refuse the "killer vaccine".

While there is no reliable evidence, it is worth noting that the presidents of Tanzania and Burundi died under mysterious circumstances.

Haiti was until recently the only country in the Western Hemisphere which refused categorically to implementing the mRNA vaccine

In a bitter irony, immediately following president Jovenel Moise’s assassination (July 7, 2021), president Joe Biden promptly sent half a million vaccine doses (and more to come) (courtesy of Uncle Sam) which were delivered by COVAX to Port au Prince six days later on July 14.


This first shipment to Haiti was  part of a US Aid program consisting of 500 million doses of the "killer vaccine" which is slated to be sent to a large number of developing countries.

The evidence is overwhelming. 

At the time of writing, almost 20,000 Covid vaccine deaths have been recorded in the European Union (July 17, 2021). 

In the US the number of registered vaccine related deaths is of the order of 12,000 (July 9, 2021).

According to the EudraVigilance database (July 17, 2021) there were  18,928 deaths and 1,823,219 injuries reported following injections of four experimental COVID-19 shots.

1 : COVID-19 MRNA VACCINE MODERNA (CX-024414).
2 : COVID-19 MRNA VACCINE PFIZER-BIONTECH.
3 : COVID-19 VACCINE ASTRAZENECA (CHADOX1 NCOV-19).
4 : COVID-19 VACCINE JANSSEN (AD26.COV2.S).

From the total of injuries recorded in the EU, “half of them (904,609) are serious injuries“. 

According to EuroViligance (quoted by by Brian Shilhavy):
"Seriousness … can be classified as ‘serious’ if it corresponds to a medical occurrence that results in death, is life-threatening, requires inpatient hospitalisation, results in another medically important condition, or prolongation of existing hospitalisation, results in persistent or significant disability or incapacity, or is a congenital anomaly/birth defect."

These are official statistics based on a formal process of registration of deaths and "adverse effects". 

The actual number of deaths and injuries triggered by the mRNA vaccine are much higher. 

Less than ten percent of the victims or families of the deceased will go through the tedious process of reporting vaccine related deaths and injuries to the national health authorities.

According to the latest "official" figures for the EU, Britain and the US (combined), there are 31,389 Covid-19 vaccine related deaths and almost 5 million injuries.

EU/EEA/Switzerland to 17 July 202118,928 Covid-19 injection related deaths and over 1.8 million injuries, per EudraVigilance Database.

UK to 7 July 2021 -1,470 Covid-19 injection related deaths and over 1 million injuries, per MHRA Yellow Card Scheme.

USA to 9 July 202110,991 Covid-19 injection related deaths and over 2 million injuries, per VAERS database.

TOTAL for EU/UK/USA31,389 Covid-19 injection related deaths and almost 5 million injuries reported so far in July 2021.

Hidden Injuries: The Microscopic Blood Clots.
The persons vaccinated will not be immediately aware of the injuries incurred. 

The latter in most cases are not discernible,  nor are they recorded. 

While "Big Blood Clots" resulting from the vaccine are revealed and reported by those vaccinated, an important study by Canada’s Dr. Charles Hoffe, suggests (yet to be fully confirmed) that the mRNA vaccine generates "microscopic blood clots".

"The blood clots we hear about which the media claim are very rare are the big blood clots which are the ones that cause strokes and show up on CT scans, MRI, etc.
The clots I’m talking about are microscopic and too small to find on any scan. They can thus only be detected using the D-dimer test."

These people have no idea they are even having these microscopic blood clots. The most alarming part of this is that there are some parts of the body like the brain, spinal cord, heart and lungs which cannot re-generate. When those tissues are damaged by blood clots they are permanently damaged.

"These shots are causing huge damage and the worst is yet to come." 

Big Pharma. Pfizer’s Near Global Monopoly.
Hundreds of billions of dollars are at stake. This is the largest and most expensive vaccine project in World history which is slated to be financed by tax dollars Worldwide, putting an obvious strain on the public debt of numerous countries.

The vaccine program is accompanied by a "timeline"  consisting of recurrent mRNA inoculations over "the next two years and beyond". 

As documented above, it will have devastating impacts on mortality and morbidity Worldwide.

What is at stake is a multi-billion dollar Big Money operation for Big Pharma with Pfizer in the lead.

Pfizer-BioNTech (allied with Moderna Inc) is in the process of consolidating its Worldwide (near monopoly) position  by pushing out its major competitors including AstraZenaka and Johnson and Johnson (J & J).

Pfizer has been pressuring politicians to endorse their mRNA vaccine

It’s political lobbying is also directed against its Big Pharma competitors

According to Bureau Investigates report:
One official who was present in the unnamed country’s negotiations described Pfizer’s demands as "high-level bullying" and said the government felt like it was being "held to ransom" in order to access life-saving vaccines.

Ironically, in the EU, the reported deaths and injuries were used by the European Commission to cancel the renewal of the contract with AstraZeneka, despite the fact that there were substantially more deaths and injuries associated with the Pfizer-BioNTech vaccine.

In April 2021, the EU Commission confirmed that it would "end AstraZeneca and J&J vaccine contracts at expiry".  

"The Pfizer shot will take precedence". 

Never mind your followup dose with AstraZeneka, the health authorities have instructed people to get their second or third jab with Pfizer or Moderna (thereby visibly violating medical norms).

Having sidelined its competitors, Pfizer-BioNTech has jacked up the price of the vaccine vial. 

Pfizer has literally cornered both the EU and US markets. 

A near global vaccine monopoly is in the making.

The European Union
In mid-April 2021 the President of the European Commission confirmed that Brussels is in process of negotiating  a contract with Pfizer for the production of 1.8 billion mRNA vaccine doses, which represents 23 percent of the World’s population.

That’s exactly four times the population of the 27 member states of the European Union (448 Million, 2021 data), which confirms that several followup doses of the "killer vaccine" are envisaged, despite the trend in mortality and morbidity which the governments and the media are attempting to suppress as part of a  hideous disinformation campaign.

Pfizer and the US Market
A similar pattern is occurring in the US and Canada. In July 2020, Pfizer signed a $1.95 billion contract with the U.S. government for 100 million doses

And then in December 2020 another 100 million doses were delivered.

In Canada, another 35 million doses of Pfizer and Moderna vaccine vials are slated to be delivered.

And now July 2021 the Biden administration has ordered 200 million more doses of the Pfizer vaccine

"for children’s shots and possible boosters"

But that’s not all: in early June 2021, Biden ordered 500 million Pfizer-BionTech doses of the "killer virus" to be sent as "US Aid" to developing countries (courtesy of Uncle Sam).

In most Western countries including the US and Canada, the retail price of the vaccine is "Free".

In the US, a total of 900 million doses of Pfizer-BionTech vaccine vials is Big Money for Big Pharma: Massive profits for Pfizer, all of which are slated to be financed by tax revenues coupled with a dramatic expansion of the US public debt.
In the first quarter of  2021 (January through March 2021), the gross revenues accruing to Pfizer and Moderna were as follows:

#1. Pfizer-BioNTech COVID-19 vaccine. U.S. sales were $2.038 billion; global sales were $5.833 billion.

#2. Moderna COVID-19 vaccine. U.S. sales, $1.358 billion; global sales, $1.733 billion.

Recently announced (23 July 2021), Pfizer has jacked up the price of its vaccine vial from $19.50 to $28.00.

Multiply $28.00 by three vaccine doses per person for a World population of 7.9 billion, What do you get?

This is not an estimate, it’s an "order of magnitude": 663.6 billion dollars  ($28.00 x 3 x 7.9 billion = $663.6 billion).

It is all for a good cause: save lives?

We are talking about a multi-billion dollar operation at tax payers expense, which has resulted in a pattern of vaccine related deaths and injuries. And the governments are fully aware of what is happening.

Pfizer’s Criminal Record
Is Pfizer "a reliable partner" as claimed by the EU Commission President van der Leyen?
A global vaccine monopoly is unfolding controlled by a company which has a criminal record (2009) with the US Department of Justice.

It was not the routine civil class action law suit waged against the pharmaceutical industry. 

It was a criminal indictment for "fraudulent marketing".

While there were no arrests, Pfizer was so to speak "Put on Parole" under a US DOJ indictment.

In a historic US Department of Justice decision in September 2009, Pfizer Inc. pleaded guilty to criminal charges. 

It was "The Largest Health Care Fraud Settlement" in the History of the U.S. Department of Justice.


Pfizer to Acquire A Near Monopoly of the Global Covid Vaccine Market
And now among all major Big Pharma actors, it’s a company with a criminal record which has established a de facto near monopoly at a World Level.

Can we trust a Big Pharma vaccine conglomerate which pleaded guilty to criminal charges by the US Department of Justice (DoJ) including "fraudulent marketing" and "felony violation of the Food, Drug and Cosmetic Act"?

"Fraudulent marketing" in the case of the Pfizer-BioNTech’s  "killer vaccine" is a gross understatement. 

What is Value of   Human Life? 

It does not have a monetary value.

Can we trust the politicians in high office who granted these multibillion Euro/dollar contracts to Pfizer, which are funded by tax revenues.

Is this a "mistake" on the part of the national health authorities? 

The experimental mRNA "vaccine" has resulted in an upward trend in  mortality and morbidity Worldwide. 

Meanwhile, Big Pharma profits are in the hundreds of billions.

And governments, acting on behalf of Big Pharma are pressuring people to get vaccinated to no avail imposing penalties to those who refuse.

National health authorities claim that the Covid-19 "vaccine" will save lives. That’s a lie.

Do we Know What’s inside the Pfizer Vaccine Vial?
The causes of vaccine related deaths and injuries have not been addressed by the health authorities.

What is inside the vaccine vial? 

National health authorities have not made public the results of their lab exams. 

It is unclear as to whether those lab exams of the vaccine vials have been conducted.

Graphene Oxide Nano-particules.
According to lab exams conducted by the Spanish Quinta Columna research team, graphene oxide nano-particles have been detected in the vial of the Pfizer mRNA vaccine.

The results of their research (analysis by electron microscopy and spectroscopy) are far-reaching. 

Graphene oxide is a toxin which triggers thrombi and blood coagulation

It also has an impact on the immune system. 

Graphene oxide accumulated in the lungs can have devastating impacts.

The results of the Spanish study, yet to be fully confirmed and ascertained, suggest that the recorded vaccine related deaths and "adverse events" (quoted above for the EU, UK and US) could be the result of graphene oxide nano-particles contained in the Covid vaccine vial.

This is a controversial study. 

There are scientists and medical doctors who disagree with the results of the Spanish study.

The evidence has to be either ascertained or refuted. 

What is required is that independent scientists and health professionals conduct their own lab analysis of the contents of the vaccine vial.

Similarly, we call upon the national health authorities of the 193 member states of the UN which are currently vaccinating their people, to conduct their own study and analysis of the vaccine vial. 

And if graphene-oxide is detected, the vaccination program should immediately be discontinued. 

Also of significance, (acknowledged by national health authorities) graphene oxide nano-particles are also contained in the face mask.
 
The Electromagnetic Properties of the mRNA Vaccine.
What is triggering the electromagnetic effects which have been detected in people who have been vaccinated?

These effects have been amply documented and confirmed by independent sources including those vaccinated. 

The national health authorities have failed to provide an explanation.

See the study conducted by the European Forum for Vaccine Vigilance.

Concluding Remarks. The Vaccine Passport.
The data from official sources quoted above confirm unequivocally that the Covid-19 "vaccine" has resulted in an upward trend in vaccine related mortality and morbidity.

In turn, the studies of Dr. Charles Hoffe and the Spanish Research Team (Quinta Columna) which remain to be fully ascertained, point to possible "future impacts" of the vaccine  on human health.

According to official data based on reported / registered deaths and injuries, there is no doubt: this is a "killer vaccine".

So why are governments pressuring people to get vaccinated?
Heads of State and heads of government Worldwide are being pressured, bribed, coopted and/or threatened by powerful financial interests into accepting the Covid vaccine consensus.

The vaccine passport is the endgame, which constitutes a transition towards digital tyranny.

At the time of writing, the vaccine passport has already been imposed in several countries including France and Italy.

In France, this was not an initiative of president Emmanuel Macron (it was imposed upon him). 

Macron is a political proxy acting on behalf of the financial and billionaire foundations. 

Macron is a former bank staff of the Rothschilds.

In turn, the Italian Prime Minister Mario Draghi (former president of the European Central Bank) is an instrument of Goldman Sachs.


Bill Gates has play a key role. 

His foundation finances the WHO.

He has developed ties at a personal level with numerous heads of state and heads of government in all major regions of the World with a view to effectively carrying out this vaccine project.


The global capitalist elites control the so-called "classe politique". 

The governments are liars.

From the very outset, the unspoken objective of the corona crisis (based on lies and deception) was to ultimately impose the contours of a Worldwide totalitarian regime, entitled "Global Governance" (by unelected officials). 

In the words of the late David Rockefeller:

“…The world is now more sophisticated and prepared to march towards a world government. The supranational sovereignty of an intellectual elite and world bankers is surely preferable to the national auto-determination practiced in past centuries.” (quoted by Aspen Times, August 15, 2011, emphasis added)
The Global Governance scenario imposes an agenda of social engineering and economic compliance.

The "intellectual elite" referred to by David Rockefeller is made up of numerous generously funded "scientists", "technocrats" and "scholars" (e.g. Drosten, Neil Ferguson, et al) whose models and research findings have been used to justify the lockdown policies and the "killer vaccine".
 
The mRNA vaccine should be halted and discontinued immediately Worldwide.

The Protest Movement. Bastille 2.0

Acts of protest and resistance must question the legitimacy of both the financial architects of this crisis as well as the governments involved in imposing the vaccine:

The legitimacy of politicians and their powerful corporate sponsors must be questioned, including the police state measures adopted to enforce the closure of economic activity, the imposition of a digital vaccine passport as well as the wearing of the face mask, social distancing, etc.

This network must be established (nationally and internationally) at all levels of society, in towns and villages, work places, parishes. 

Trade unions, farmers organizations, professional associations, business associations, student unions, veterans associations, church groups would be called upon to integrate this movement.

The first task would be to disable the fear campaign and media disinformation as well put an end to Big Pharma’s Covid vaccination programme.

The corporate media should be directly challenged, without specifically targeting mainstream journalists, many of whom have been instructed to abide by the official narrative. 

This endeavour would require a parallel process at the grassroots level, of sensitizing and educating fellow citizens on the nature of  virus, the impacts of the vaccine and the lockdown.

"Spreading the word" through social media and independent online media outlets will be undertaken bearing in mind that Google as well as Facebook are instruments of censorship.

The creation of such a movement, which forcefully challenges the legitimacy of the financial elites as well as the structures of political authority at the national level, is no easy task. 

It will require a degree of solidarity, unity and commitment unparalleled in World history.

It will also require breaking down political and ideological barriers within society (i.e. between political parties) and acting with a single voice.

We must also understand that the "corona project" is an integral part of the U.S. imperial agenda. 

It has geopolitical and strategic implications. 

It will also require eventually unseating the architects of this diabolical "pandemic" and indicting them for crimes against humanity. (Michel Chossudovsky, December 2020. With some minor changes)

In the words of Doctors for Covid Ethics:

The Gene-based "Vaccines" are Killing People. 

Governments Worldwide Are Lying to You the People, to the Populations They Purportedly Serve.


 JAPAN HALTS
1.6 MILLION MODERNA VACCINE
AFTER DISCOVERING
METAL FOREIGN SUBSTANCES
By
Søren Nielsen
2021


Key facts.
According to Kyodo News, foreign substances—a few millimeters in size—were confirmed in at least 39 unused vials of the vaccine, with their elements being unknown.

As a precaution, Moderna is suspending the supply of about 1.63 million doses that it suspects were manufactured on the same production line in Spain.

The vaccine maker claims that only 565,400 doses were part of the same production lot as the contaminated doses, but decided to also put a hold on two adjacent lots "out of an abundance of caution."

Moderna is now conducting an investigation into the nature of the foreign materials, the Japanese ministry said.

Japanese pharma giant Takeda, which handles the sales and distribution of the vaccine in the country, said it has yet to see any reports of safety concerns.

Takeda, however, has informed medical institutions and other entities to not use any doses which appear abnormal or show any signs of contamination, including doses not subject to the suspension.

Key Background.
The vaccine setback comes at a time when Japan is witnessing its worst outbreak of the entire pandemic. 

Fueled by the highly infectious delta variant, the country is reporting an average of around 23,000 new cases every single day. 

The one bright spot in Japan’s pandemic management has been the recent speed of its vaccine rollout. 

After a sluggish start, Japan has now fully inoculated nearly 43% of its population. 

On Wednesday, Prime Minister Yoshihide Suga said that the country is on track to inoculate around 60% of its population by the end of September and it has enough vaccine doses in reserve for a potential booster dose if that is needed.

Japan’s Ministry of Health, Labour and Welfare suspended the use of more than 1.6 million doses of Moderna’s Covid-19 vaccine Thursday following reports of contaminated vials at multiple vaccination sites there.

Takeda Pharmaceuticals, which distributes the vaccine in Japan for Moderna, said it notified the ministry after several vaccination sites reported an unspecified foreign object found in one specific lot.

"We requested that Moderna, the product owner and manufacturer, conduct a thorough investigation to determine the precise root cause of the issue," Takeda said in a statement.

Takeda also said that it is not aware of any "significant safety concerns" stemming from the contaminated doses.

Moderna said it’s been notified of the problem and is looking into it.

"The company is investigating the reports and remains committed to working expeditiously with its partner, Takeda, and regulators to address this," Moderna wrote in a statement.

Moderna said it believes the manufacturing issue was generated in one of the lines used at its contract manufacturing site in Spain, adding that it didn’t appear to affect the safety or efficacy of the shots.

"Given the company’s priority to assure quality, and out of an abundance of caution, Moderna has put this lot and two adjacent lots on hold," the company said.

Rovi, the Spanish pharma company that bottles Moderna vaccines, said it is investigating the situation and that the contamination seems to be limited to some batches meant to be distributed to Japan, according to Reuters

Rovi shares dropped 13% in midday trading.

Takeda discovered the contaminated vials on Aug. 16 and reported it to Japanese officials on Wednesday, according to NBC News

The company said the delay was because the contamination of the vials and affected countries needed to be confirmed.

Japan’s chief cabinet secretary, Katsunobu Kato, told reporters Thursday that contaminated doses were administered to an unknown number of Japanese residents, though there have been no reports of ill effects, according to The New York Times.

Doses from the contaminated lot were administered between Aug. 6 and Aug. 20 at a vaccination site in Osaka run by Japan’s defense ministry, according to Reuters, but it is unclear if any of the doses used were contaminated.

Doses from the contaminated lot were set to be used at mass vaccination sites at large companies and universities, but all have been halted, according to Reuters.

All of the contaminated vials were manufactured in Spain

It is still unclear if other countries besides Japan have been affected, though the European Medicines Agency said it’s also looking into the issue.

"EMA is investigating the matter and has requested the marketing authorisation holder to provide information on any potential impact on batches supplied to the EU in addition to details on the ongoing root cause investigation," the agency said in a statement to Reuters.

Moderna told CNBC there is "no evidence" that other countries could have been affected because "the lot comes from a batch that was manufactured exclusively for Japan."

Moderna said there is no "expected timeframe for completion" of the investigation into the contaminated doses but that it is working with its contract manufacturer, its distributor and the government.


lørdag den 11. september 2021

EMERGENCY ALERT!
BRITISH GOVERNMENT WARNS 
COVID VACCINE MAY KILL 2.6 BILLION PEOPLE ACROSS THE PLANET
By
Søren Nielsen
2021



We have watched SARS-CoV-2 develop for 18 months and have some idea of its trajectory. 

The Delta variant is the prime example of strains succeeding each other, becoming progressively worse in waves of infection. 

According to a recent report from the Scientific Advisory Group for Emergencies (SAGE) in the United Kingdom, the virus is very likely to evolve into a still more dangerous form. 

We must be prepared for this outcome, for we are already behind the curve as SARS-CoV-2 is outpacing our response.

Intended for reference by Prime Minister Boris Johnson and key public health decision-makers, the report compiled by leading physicians, scientists, and epidemiologists outlines what is known about viral evolution presents scenarios we are likely to encounter in the coming months and years as the Delta variant continues to evolve into something even more dangerous. 

The report assigns probabilities for each scenario and recommends strategies to limit the damage and control the pandemic.

The report outlines four scenarios: 

Scenario one: The Delta variant mutates to a point of increased lethality. Under this scenario, the virus has the potential to kill between 10 and 35% of people infected, as did SARS-CoV and MERS-CoV, up from the 1 to 2% lethality, characteristic of the current strains.

Scenario two: The Delta variant mutates to evade vaccines.

Scenario three: The Delta variant mutates to a point of multi-drug resistance, challenging antiviral treatments designed to prevent and treat disease. 

Scenario four: The Delta variant mutates to become less harmful, similar to the four coronaviruses circulating today, such as the common cold.

Before dissecting these scenarios, it is important to recognize the basis of their conclusions. 

The report is cognizant of the behavioral patterns of viruses and coronaviruses in particular. 

They can alter their genetic structures by mutation and recombination, leading to substantial changes in fundamental characteristics, including replication rate, transmission efficiency, and pathogenesis.

In what follows, we provide a detailed summary and analysis of each scenario.

Scenario One: Increased Lethality 

The SAGE report considers the development of strains with increased lethality a realistic possibility.

The Delta variant has driven a rise in cases to levels we have not observed in the United States since mid-February, and recent data shows a surge in deaths related to Delta variant infection in the UK, their highest rates since mid-March. 

The SAGE report highlights the possibility of recombination between two aggressive variants, resulting in a new, substantially more lethal and virulent virus. 

Specifically, the report highlights the possibility of an alpha and beta variant recombination. 

Were these variants to recombine, the variant could be comprised of the best of both worlds, forming a variant of dangerous transmission and immune evasion.

The report highlights another likely origin of a more pathogenic virus through the current advent of antigenic drift. 

Orf and structural proteins are particularly important in the suppression of host immune responses. 

Orf9b, for example, suppresses innate immunity by targeting mitochondria and the mitochondrial antiviral signaling protein (MAVS), TNF receptor-associated factor 3 (TRAF3), and TRAF6

In the alpha variant, a single amino acid mutation in the latter portion of the genome enabled the virus to replicate Orf9b mRNA to 80-fold greater amounts than in non-alpha variant samples.

As the report notes, the "likelihood of genotypic change in internal genes...is high." 

So long as infections continue, the virus will continue to mutate to better adapt to its host environment: us. 

If a single amino acid outside the S protein could enhance an immune suppression function by 80-fold, imagine the evolutionary capacity of dozens of other fine-tuned mutations down the line.

Scenario Two: Evading Vaccines

The SAGE report considers the possibility that the virus will develop into what I call "vaccine-busting variants" to be an almost certainty.

Influenza is an effective model for their concern. 

In addition to successive antigenic mutations that avoid immune suppression, a coronavirus has the evolutionary capability of antigenic shift, which involves substituting one or more genomic segments from a prevalent strain to an unrelated strain of animal origin. 

Such antigenic shifts of Influenza have occurred three times over the past century, each time giving rise to a new strain of flu, which evades existing prior immunity.

We note that a number of human and other animal retroviruses make use of the same ACE2 receptor as SARS-CoV-2, and given that hundreds of millions of people around the world have been and will be infected with SARS-CoV-2, it is highly likely that such a recombination event could take place.

At present, we are witnessing real-time antigenic drift, which could also result in "vaccine-busting variants." 

Each variant, as they arise, contains a series of point mutations in the exterior spike protein, which serve to reduce the potency of extant vaccines and monoclonal antibodies. 

Observations based on the annual recurrence of cold-causing coronaviruses indicate that the virus has nowhere near exhausted its capacity to reduce recognition by antibodies produced by previous infection or vaccine.

Scenario Three: Anti-Viral Drug Resistance

The SAGE report considers the possibility that the virus will develop antiviral drug resistance to be likely.

The development of potent small-molecule antiviral drugs has been slower than originally anticipated. 

A problem plaguing the development of antiviral drugs is a long asymptomatic period prior to the onset of symptoms. 

By the time symptoms typically appear, the concentration of the virus has rapidly dropped in infected people and further treatment by anti-viral drugs yields limited efficacy. 

There are two strategies to counter. 

One is much more vigorous, which is the early identification of the infected, contact tracing, and use of antiviral drugs for prophylaxis. 

That has been a successful approach with monoclonal antibodies. 

The Regeneron combination monoclonal antibody was recently approved by the United States for preventing infections in nursing homes and other congregate living settings.

Resistance to single and, in some cases, multiple monoclonal antibodies is already apparent. 

Many of the variants can no longer be neutralized by monoclonal antibodies that were produced early in the pandemic. 

Reports from separate laboratory studies show that single combinations of small molecule drugs also result in rapid adaptation and resistance. 

The lessons learned from successful treatment and prophylaxis of HIV show that combinations of antiviral drugs are critical for both the prevention and treatment of HIV infections

Combination treatment with two or more drugs dramatically reduces the possibility that the virus would rapidly develop resistance. 

Currently, there are more than 25 drugs, focusing on at least five or five to six different HIV targets that are used in combination.

It is likely that a successful program for chemoprevention and treatment of coronaviruses requires a similar large pharmacopeia to cope with the virus’s propensity for developing resistance. 

The report urges dramatically increased research on the development of antiviral drugs. 

The model could be the recent drug, Xofluza, which was developed to prevent household transmission and length of influenza, and has been shown to reduce infection duration by 80% when administered promptly post-exposure to active Influenza infection. 

Scenario Four: Decreased Virulence

The SAGE report considers the possibility that the virus will develop decreased virulence to be a realistic possibility, only in the long term.

It is possible, but by no means certain, that over time the virus could mutate through a form that is highly transmissible but far less lethal. 

This may have been the case for the four coronaviruses currently in circulation, although there is no hard evidence to support this speculation. 

The report mentions that it is unlikely that the virus will mutate to become less lethal in the near future. 

They suggest that if the virus does mutate to a less lethal form, such mutations may occur over a period of many years to many decades.

This report is not entirely pessimistic. 

It offers a number of different approaches; many of these involve additional research and vaccines which may produce better immune responses, capable of protection from many different viruses. 

The report also calls for major increases in fundamental and applied research of coronaviruses to fill in glaring gaps in our knowledge necessary to create new generations of vaccines and antiviral drugs. 

Finally, the report mentions that we are not helpless in the face of these viral changes. 

Human behavior is a driving factor in the spread of the virus. 

Behavior modifications including mask-wearing, isolation, lockdowns, contact tracing, all combined with vaccines and antiviral drugs—something I am calling "Multimodal Covid Control"—holds a prospect for effective management of the Covid-19 pandemic.

An Engineered Doomsday
It concerns recent avian influenza H5N1 research, in which scientists in the Netherlands and at the University of Wisconsin found that by passaging the virus in ferrets it could acquire aerosol transmissibility. 

Let’s determine if the scientific facts warrant the frightening title.

The editorial begins by rebuking the scientists who carried out the experiments on H5N1:

"…the research should never have been undertaken because the potential harm is so catastrophic and the potential benefits from studying the virus so speculative.…they created a virus that could kill tens or hundreds of millions of people if it escaped confinement or was stolen by terrorists. …the new virus…ought to be destroyed."

The intent of the experiments was not to create a doomsday virus, but to answer questions about why the H5N1 virus transmits well among birds but not humans. 

This experiment cannot of course be done in humans, so it was carried out in ferrets, a model for influenza

The results show that aerosol transmissibility in ferrets can be achieved with just five amino acid changes, with no reduction in the virulence of the virus. 

That result does not mean that the same amino acid changes would have the same effect in humans – it just tells us that achieving aerosol transmissibility in an animal model is relatively easy.

Whether tens or hundreds of millions of people would be killed depends on the ability of a virus to not only transmit among humans, but to retain virulence. 

There is no evidence that the ferret-passaged H5N1 virus has these properties. 

In the unlikely event that the virus somehow escaped and began to infect people, its spread could be controlled by vaccines (candidates are under development) and antivirals (existing neuraminidase inhibitors are active against influenza H5N1).

The heart of the H5N1 controversy is encapsulated by the next passage:

"Thus far the virus has infected close to 600 humans and killed more than half of them, a fatality rate that far exceeds the 2 percent rate in the 1918 influenza pandemic that killed as many as 100 million people."

This statement refers to the fact that nearly 60% of the 573 WHO-confirmed H5N1 cases have died

This death rate appears staggering until one considers how it is calculated. 

The WHO case definition for H5N1 influenza states that an individual must have a febrile respiratory illness, known exposure to H5N1 virus in the previous 7 days, and confirmation of infection by virus culture, polymerase chain reaction, or tests for antibodies. 

These conditions are highly unlikely to be fulfilled in rural populations where most H5N1 infections probably occur. 

The case fatality ratio can only be calculated by dividing the number of deaths by the total number of infections – and we do not know the latter number. 

Of ten large studies that have tested for H5N1 antibodies in rural populations, two were negative and 5 reported the presence of H5 antibodies in 0.25.6% of indiviudals. 

Much more work needs to be done to determine the actual fatality rate of influenza H5N1, but the WHO estimate is orders of magnitude too high.

Next the Editors weigh in on publication of the ferret results:

"The Erasmus team believes that more than 100 laboratories and perhaps 1,000 scientists around the world need to know the precise mutations to look for. That would spread the information far too widely. It should suffice to have a few of the most sophisticated laboratories do the analyses."

As I have argued before, limiting the dissemination of scientific information only serves to impede progress. 

It is impossible to predict which laboratory is going to do the breakthrough experiment, and picking "sophisticated" laboratories is meaningless.

Then the Editors argue that the research has no value:

"Defenders of the research in Rotterdam claim it will provide two major benefits for protecting global health. But it is highly uncertain, even improbable, that the virus would mutate in nature along the pathways prodded in a laboratory environment, so the benefit of looking for these five mutations seems marginal."

I would like to see the studies on which this statement is based. 

It is well known in virology that mutations selected in laboratory experiments can be been identified in nature. 

For example, the mutations identified in the H5N1 influenza viruses that transmit among ferrets have indeed been observed naturally in animals. 

The fact is that no particular viral mutation is improbable, given the enormity of  viral diversity in nature.

The Editors write that the results of the H5N1 studies do not help determine if existing antiviral drugs and vaccines would be effective:

"But genetic changes that affect transmissibility do not necessarily change the properties that make a virus susceptible to drugs or to the antibodies produced by a vaccine, so that approach may not yield much useful new information."

Two of the currently used drugs for controlling influenza, Tamiflu and Relenza, act by inhibiting the viral neuraminidase enzyme. 

Its function is to allow viruses to spread from cell to cell, and could very likely be involved in ferret transmission. 

If changes in this protein lead to aerosol transmission among ferrets, they could alter sensitivity to the drugs. 

Other changes in the H5N1 virus might alter its protein profile, making it less sensitive to currently proposed vaccines. 

These are only two of many reasons why studying this H5N1 virus would yield a great deal of useful information. 

As noted in A flu virus risk worth taking by Anthony Fauci, Gary Nabel, and Francis Collins in the Washington Post

“…new data provide valuable insights that can inform influenza preparedness and help delineate the principles of virus transmission between species.”

I think it is a good idea to have a public dialogue to understand the goals of influenza H5N1 research. 

But the discussion should be based on scientific fact, not doomsday scenarios.